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See Latest ArticlesIncreased serum pentraxin 3 in patients with systemic sclerosis
Journal of Rheumatology, 05/19/09
Iwata Y et al. – Findings suggest that elevated serum pentraxin 3 (PTX3) levels are associated with the disease severity of systemic sclerosis (SSc).
Methods- Study to determine serum concns of PTX3 and its clinical associations in:
- 45 pts with diffuse cutaneous SSc (dSSc)
- 46 pts with limited cutaneous SSc (lSSc), and
- 20 healthy controls
examined by ELISA
- PTX3 expression in the sclerotic skin from SSc pts was evaluated IHC
- Normal and SSc fibroblasts were cultured and PTX3 levels in the culture medium were also examined by ELISA
- Serum PTX3 levels were elevated in pts with SSc vs controls
- PTX3 levels in dSSc pts were higher than in controls and lSSc pts
- PTX3 expression in the sclerotic skin from SSc pts was more intense relative to normal skin
- Elevation of serum PTX3 levels was associated with more frequent presence of:
- pulmonary fibrosis
- cardiac disease, and pitting scar/ulcer and
- increased serum immunoglobulin levels and ESR
- PTX3 levels correlated positively with:
- modified Rodnan total skin thickness score
- serum levels of 8-isoprostane, a marker of oxidative stress, and
- hyaluronan, recently identified as an endogenous ligand for Toll-like receptors
- PTX3 levels were negatively correlated with % vital capacity and % DLCO in pts with SSc
- PTX3 production from cultured SSc fibroblasts was increased by stimulation with hyaluronan
Today in Basic Science/Genetics...keeping you current
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Today in Diagnostics/Radiology...keeping you current
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Is there any relationship between serum and urine neopterin and serum interferon-gamma levels in the activity of Behcet's disease?
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