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See Latest ArticlesPeripheral arterial stiffness and endothelial dysfunction in idiopathic and scleroderma associated pulmonary arterial hypertension
Journal of Rheumatology, 05/18/09
Peled N et al. – Findings show a trend towards increased arterial stiffness in scleroderma and towards peripheral endothelial dysfunction in idiopathic-pulmonary arterial hypertension (PAH) and in scleroderma-PAH, suggesting involvement of different vessels in scleroderma-PAH VS idiopathic-PAH.
Methods- Study of systemic arterial stiffness and endothelial involvement in idiopathic- and scleroderma-associated PAH
- Subjects: 28 with idiopathic- and 10 with scleroderma-associated PAH and 21 controls
- Clinical and cardiopulmonary evaluation for all pts
- Measurement of arterial stiffness by fingertip tonometry for augmentation index (AI)
- Measurement of endothelial function by forearm blood flow dilatation response to brachial artery occlusion by noninvasive plethysmography
- Mean systolic pulmonary pressure: 70.5 ± 21.6 mm Hg (idiopathic-PAH); 69.3 ± 20 mm Hg (scleroderma-PAH)
- AI higher in scleroderma pts
- PAT ratio lower than control values in idiopathic-PAH and scleroderma-PAH
- AI not correlated to endothelial dysfunction
- No differences between 2 PAH ptgroups in age, BMI, New York Heart Association classification, or 6-min walk test
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