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Assessment of active spinal inflammatory changes in patients with axial spondyloarthritis: Validation of whole body MRI against conventional MRI
Annals of Rheumatic Diseases, 05/08/09

Weber U et al. – Study demonstrates that the whole body (WB) and conventional (CON) MRI scores showed a high correlation and comparable high reliability for the detection of active inflammatory lesions in the spine of patients with clinically active spondyloarthritis (SpA).

Methods

An evaluation of the performance of WB MRI vs CON MRI in assessing active inflammatory lesions of spine in SpA pts
32 consecutive SpA pts with BASDAI score ≥4 were scanned by sagittal WB and CON MRI
The MR images were scored independently in random order by 3 readers
Active inflammatory lesions of the spine were recorded on a web-based scoring form

Results

Median percentage of inflammatory lesions recorded concordantly for both WB and CON MRI ranged from 83% to 91% for the 3 readers
- 4% to 9% were only recorded by WB MRI
- 4% to 9% were recorded by CON MRI only
Pearson correlation coefficient between WB and CON MRI per rater was 0.79, 0.89 and 0.81, respectively
The ICC(2, 1) for CON MRI was 0.75, 0.80 and 0.68 and for WB MRI 0.82, 0.83 and 0.93, respectively, for the 3 possible reader pairs

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