Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Rapid correction of low vitamin D status in nursing home residents 3. 2008 Exclusive Survey—Earnings: Good news for primary care income 4. Medicare pay-for-reporting effort draws fire from frustrated doctors 5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment
Top Ten Searches
rheumatoid arthritis lupus polymyalgia sjogrens fibromyalgia amyloidosis vasculitis urate raynauds myositisYour Article Summary
See Latest ArticlesInfluence of age at disease onset in the outcome of paediatric systemic lupus erythematosus
Rheumatology, 05/08/09
Descloux E et al. - Study reports that the risk of damage is inversely correlated with age at disease onset in paediatric systemic lupus erythematosus (pSLE). The poorer outcome observed in younger children may be explained by a more severe disease expression, higher infectious susceptibility, and a more aggressive therapy, particularly within the first 6 months of disease course.
Methods- Aim was to investigate the influence of age at disease onset in the outcome of pSLE
- 56 pts; divided into 3 groups: pre-pubertal, peripubertal and post-pubertal onset
- The SDI (SLICC/ACR Damage Index for SLE), pts’ characteristics, disease manifestations and treatments were compared
- Risk of damage (SDI ≥1) decreased when age at disease onset increased
- This excess of risk was found in all disease duration intervals studied and at the end of f/u
- Kaplan–Meier curves indicated a higher and earlier risk of damage in younger pts
- Young children showed higher frequency of autoimmune family history
- Frequency of neuropsychiatric disorders and damages decreased with age at disease onset
- Cumulative duration of high-dose prednisone and number of immunosuppressive drugs used contributed to damage increased when age at disease onset decreased
Related Articles
B lymphocyte stimulator expression in pediatric systemic lupus erythematosus and juvenile idiopathic arthritis patients
Arthritis & Rheumatism, 11/04/09
Relevance Score: 70%
Whats new in paediatric SLE
Best Practice & Research: Clinical Rheumatology, 10/29/09
Relevance Score: 67%
Acute epiglottitis as the initial presentation of pediatric Systemic Lupus Erythematosus
Pediatric Rheumatology, 11/10/09
Relevance Score: 66%
Macrophage activation syndrome in juvenile systemic lupus erythematosus: A multinational multicenter study of thirty-eight patients
Arthritis & Rheumatism, 11/06/09
Relevance Score: 65%
Neuropsychiatric Systemic Lupus Erythematosus Presenting as Bipolar I Disorder With Catatonic Features
Psychosomatics, 10/29/09
Relevance Score: 65%
Today in Pediatric Rheumatology...keeping you current
Receive free subspecialty "5-minute updates" via email
A case of juvenile idiopathic polyarticular arthritis complicated by IgA deficiency in 22q11 deletion syndrome
Rheumatology International, 12/19/09
Do infections trigger juvenile idiopathic arthritis
Rheumatology International, 12/17/09
The role of exercise therapy in the management of juvenile idiopathic arthritis
Current Opinion in Rheumatology, 12/16/09
Today in Systemic Lupus (SLE)...keeping you current
Receive free subspecialty "5-minute updates" via email
A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population
Rheumatology International, 12/19/09
The role of anti-alpha-actinin antibodies in the pathogenesis and monitoring of lupus nephritis
Arthritis Research & Therapy, 12/19/09
Clinical features and prognosis of late-onset systemic lupus erythematosus: results from the 1000 faces of Lupus Study
Journal of Rheumatology, 12/17/09
Sponsor
Article Search
Sponsor
Sponsor