Rheumatology Medical News about lupus;Anti-TNF-induced

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Anti-TNF-induced lupus
Rheumatology, 05/07/09

Williams EL et al. - Anti-TNF-α therapies commonly used in the treatment of chronic inflammatory human diseases, including RA, PsA, AS and Crohn's disease are the latest class of medications found to be associated with a ‘lupus-like’ syndrome. All of these have a range of adverse effects in common, including the formation of autoantibodies and the development of drug-induced lupus (DIL). It is unclear at this stage whether these cases are ‘typical’ DIL or represent a distinct syndrome of ‘anti-TNF-induced lupus’ (ATIL). This review article concludes that:

Autoantibody induction is common with anti-TNF but ATIL is rare
ATIL appears distinct from classical DIL with a phenotype more similar to idiopathic SLE
ATIL is generally self-limiting after stopping anti-TNF therapy but may require corticosteroids and immunosuppressives

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