Rheumatology Medical News about ankylosing spondylitis;MRI;response to anti-TNF

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MRI predicts response to anti-TNF in ankylosing spondylitis
International Journal of Clinical Rheumatology, 05/07/09

Rudwaleit M et al. – Findings recommend the clinical, serological and radiological factors to be used, either individually or in combination, to predict response to anti-TNFs in patients with ankylosing spondylitis (AS).

Methods

Aim of this study was to identify predictors of response to anti-TNF in AS

Results

The extent of inflammatory lesions on spinal MRI can be used as a predictor of response to anti-TNF
Pts with a high Berlin MRI spinal score (≥11) have an increased likelihood ratio (LR: 6.7) of a major clinical response
In combination with other predictors of response, CRP levels of 40 mg/l or more and disease duration of >10 yrs give a probability of having a major response to anti-TNF of 99.1%

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