Rheumatology Medical News about RA;enhanced reactivity to pain

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Enhanced reactivity to pain in patients with rheumatoid arthritis
Arthritis Research & Therapy, 05/07/09

Edwards RR et al. – These findings highlight the importance of pain as a stressor in rheumatoid arthritis (RA) patients, and documents the amplified responses to pain in these pts.

Methods

Study to compare the psychophysical and physiological responses to standardized noxious stimulation in 19 RA pts and 21 healthy controls
Participants underwent a single psychophysical testing session in which responses to a variety of painful stimuli were recorded
Blood samples were taken at multiple time points to evaluate the reactivity of cortisol, IL-6, and TNF-α to the experience of acute pain

Results

RA pts displayed a fairly general hyperalgesia to mechanical and thermal stimuli across several body sites
In addition, while serum cortisol levels did not differ at baseline or following pain testing in pts, an elevations in serum IL-6, and enhanced pain-reactivity of serum levels of TNF-α was demonstrated

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