Rheumatology Medical News about Fibromyalgia; dysfunctional pain inhibition

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Evidence of dysfunctional pain inhibition in fibromyalgia reflected in rACC during provoked pain
Pain, 05/07/09

Jensen KB et al. – Data validate previous reports of dysfunctional endogenous pain inhibition in fibromyalgia (FMS) and advance the understanding of the central pathophysiologic mechanisms, providing a new direction for the development of successful treatments in FMS.

Methods

An evaluation of the cerebral response to individually calibrated pain provocations of a pain-free body region
Subjects: 16 female FMS pts and 16 age-matched controls
Brain activity was measured using functional MRI (fMRI) during individually calibrated painful pressures representing 50 mm on a VAS ranging from 0 to 100 mm

Results

Pts exhibited higher sensitivity to pain provocation as they required less pressure to evoke equal pain magnitudes
Despite lower pressures applied in pts at VAS 50 mm, the fMRI-analysis revealed no difference in activity in brain regions
However, in the primary link in the descending pain regulating system pts failed to respond to pain provocation
The attenuated response to pain in this brain region is the first demonstration of a specific brain region where the impairment of pain inhibition in FMS pts is expressed

<< Previous
The decrease of soluble RAGE levels in rheumatoid arthritis...

Next >>
Gout: New advances in the diagnosis and management of an old...