Rheumatology

Your Article Summary

See Latest Articles

Coexpression of CD177 and membrane proteinase 3 on neutrophils in antineutrophil cytoplasmic autoantibody-associated systemic vasculitis: Anti-proteinase 3-mediated neutrophil activation is independent of the role of CD177-expressing neutrophils
Arthritis & Rheumatism, 05/06/09

Westra NHJ et al. – Study reports that membrane expression of CD177 on circulating neutrophils is increased in pts with ANCA-associated systemic vasculitis (ASV) and in those with SLE, but not in RA patients. However, primed neutrophils from CD177-negative individuals also express mPR3 and are susceptible to anti-PR3-mediated oxidative burst, suggesting that recruitment of CD177-independent mPR3 is involved in anti-PR3-induced neutrophil activation.

• Study was undertaken to:
  • assess the differential expression of CD177 on neutrophils from pts with ASV vs pts with SLE, RA, and healthy individuals and
  • investigate whether colocalization of mPR3 and CD177 affects anti-PR3-mediated neutrophil activation
• Expression of CD177 and mPR3 was analyzed in neutrophils from pts with ASV (n=53), SLE (n=30), and RA (n=26), and healthy controls (n=31)
• Neutrophil activation mediated by anti-PR3 Abs was assessed by measuring the oxidative burst with a dihydrorhodamine assay

• Percentages of CD177-expressing neutrophils were higher in pts with ASV and SLE vs controls
• After priming with TNF-α, neutrophils remained negative for CD177 while mPR3 expression was induced
• Neutrophils from CD177-negative donors or CD177- neutrophils were susceptible to anti-PR3-mediated oxidative burst
• Variation in the extent of anti-PR3-mediated neutrophil activation occurred independent of the percentage of CD177-expressing neutrophils

Related Articles

See all related articles

Livedoid vasculiltis associated with a double heterozygous Factor V Leiden and prothrombin G20210A gene mutations
Clinical and Experimental Dermatology, 10/08/09    Relevance Score: 66%

Churg-Strauss syndrome: evidence for disease subtypes?
Current Opinion in Rheumatology, 10/26/09    Relevance Score: 65%

Association of mannose-binding lectin gene polymorphisms with Kawasaki disease in the Japanese
International Journal of Rheumatic Diseases, 11/25/09    Relevance Score: 64%

Palisaded neutrophilic granulomatous dermatitis with leukocytoclastic vasculitis in a patient without any underlying systemic disease detected to date
Journal of Cutaneous Pathology, 11/11/09    Relevance Score: 64%

Cardiovascular involvement in Behcets disease
Clinical Rheumatology, 10/30/09    Relevance Score: 64%

Today in Vasculitic Syndromes...keeping you current

Receive free subspecialty "5-minute updates" via email

Study on association between polymorphism of HLA-DRB1 alleles and Behcet's disease
Journal of the European Academy of Dermatology and Venereology, 12/03/09

Is there any relationship between serum and urine neopterin and serum interferon-gamma levels in the activity of Behcet's disease?
Journal of the European Academy of Dermatology and Venereology, 12/03/09

Rituximab may form a complex with iGm[kappa] mixed cryoglobulin and induce severe systemic reactions in patients with hepatitis C virus-induced vasculitis
Arthritis & Rheumatism, 12/03/09

 See all of Vasculitic Syndromes