Your Article Summary
See Latest ArticlesClinical outcome of immunoglobulin light chain amyloidosis affecting the kidney
Nephrology Dialysis Transplantation, 05/06/09
Gertz MA et al. - Data suggest that presenting 24-h urine protein loss and creatinine values may predict which patients presented with immunoglobulin light chain amyloidosis (AL) will require dialysis. Median survival for pts starting dialysis is <1 year; presence of λ light chain amyloid predicts the increased likelihood of renal involvement.
Methods- Study to investigate the long-term predictors for and outcomes after renal replacement therapy in pts with AL
- Kaplan–Meier and multivariate analyses performed in a uniformly treated cohort of 145 pts monitored for 11 yrs
- Outcome measurements were needed for renal replacement therapy and survival
- Among pts presenting with renal AL, 42% received renal replacement therapy vs 5% pts w/o
- Pts with renal amyloid who received dialysis support had higher serum creatinine and 24-h urine protein levels
- Pts with λ light chain amyloid had more renal involvement and had greater urinary protein loss vs pts with κ light chain amyloid
- Serum creatinine level was an independent predictor of overall survival when corrected for cardiac involvement
- For 38 pts who received dialysis, median survival from day 1 of dialysis was 10.4 mo
- 26% of patients with AL ultimately received renal replacement therapy vs 42% of patients who presented with renal AL specifically
Related Articles
Prevention of Amyloidosis in Familial Mediterranean Fever with Colchicine: A Case-Control Study in Armenia
Medical Principles and Practice, 10/05/09
Relevance Score: 94%
Unusual Combination of Tracheobronchopathia Osteochondroplastica and AA Amyloidosis
Yonsei Medical Journal, 10/29/09
Relevance Score: 89%
A case with rheumatoid arthritis and systemic reactive AA amyloidosis showing rapid regression of amyloid deposition on gastroduodenal mucosa after a combined therapy of corticosteroid and etanercept
Rheumatology International, 10/16/09
Relevance Score: 89%
Vitreous Amyloidosis in Two Sisters as the Indication of Transthyretin-Related Familial Form of Systemic Amyloidosis Among Liver Transplantation Candidates
Transplantation Proceedings, 11/12/09
Relevance Score: 87%
Cystatin C is a sensitive marker for detecting a reduced glomerular filtration rate when assessing chronic kidney disease in patients with rheumatoid arthritis and secondary amyloidosis
Scandinavian Journal of Rheumatology, 10/02/09
Relevance Score: 87%
Today in Amyloidosis...keeping you current
Receive free subspecialty "5-minute updates" via email
Short and long-term outcome of treatment with high-dose melphalan and stem cell transplantation for multiple myeloma-associated AL amyloidosis
Annals of Hematology, 12/18/09
Clinical features and functional significance of the P369S/ R408Q variant in pyrin, the familial Mediterranean fever protein
Annals of Rheumatic Diseases, 12/11/09
MEFV mutations in Egyptian patients suffering from familial Mediterranean fever: analysis of 12 gene mutations
Rheumatology International, 10/16/09