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Anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with idiopathic inflammatory myopathy
Rheumatology, 04/27/09

Labrador-Horrillo M et al. - High titres of anti-cyclic citrullinated peptide (anti-CCP) can occasionally be found in patients with inflammatory myopathy. Therefore, a possible diagnosis of RA should be considered with caution in these patients.

Methods

Aim was to investigate the prevalence of anti-CCP and anti-keratin antibodies (AKAs) in pts with idiopathic inflammatory myopathy
90 pts; presence of anti-CCP and AKAs detected by ELISA and IIF respectively
Associations between anti-CCP and clinical manifestations or other autoantibodies were determined with the chi-square and Mann–Whitney U-tests
Radiographs of hands were retrospectively evaluated

Results

13.3% pts were positive to anti-CCP
AKAs were not detected in any patient
No clinical or biological differences between pts positive and negative to anti-CCP
Arthritis joint erosions or positive status to anti-synthetase Abs were not more frequent in pts with anti-CCP Abs
Prevalence of RF was the only variable associated with the presence of these Abs

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