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See Latest ArticlesNo effects of bosentan on microvasculature in patients with limited cutaneous systemic sclerosis
Clinical Rheumatology, 04/16/09
Hettema HE et al. - The endothelial activation marker vascular cell adhesion molecule did not change during treatment, but levels of thrombomodulin significantly decreased after 12 weeks of treatment. Bosentan did not induce significant changes in vasodilator responses, capillary permeability, and capillary density during treatment, so no evidence was obtained for structural improvement of microvascular structure and function in this short-time mechanistic pilot study in patients with lcSSc.
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Rheumatic heart disease and its control in the Pacific
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