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See Latest ArticlesIκBα promoter polymorphisms in patients with ankylosing spondylitis
Rheumatology International, 04/20/09
Hung YH et al. - Study demonstrates that IκBα-826T is associated with the development of ankylosing spondylitis (AS). Furthermore, the IκBα-881A -826T -550A -519C -297C and IκBα881A -826C -550A -519T -297C haplotypes are related to susceptibility to AS in Taiwan.
Methods- Study to investigate the association of IκBα with the development of AS in Taiwan
- 154 pts with AS and 112 unrelated healthy controls were enrolled
- The IκBα-881A/G, -826C/T, -550A/T, -519C/T, and -297C/T polymorphisms were determined by the PCR/restriction fragment length polymorphism method
- Genotype frequencies of IκBα-826C/T and -826T/T, and allele frequencies of IκBα-826T were higher in the pts with AS
- Estimated haplotype frequencies of IκBα-881A -826T -550A -519C -297C and IκBα-881A -826C -550A -519T -297C were increased in AS patient
- In contrast, the estimated haplotype frequency of IκBα-881A -826C -550A -519C -297C was decreased in AS pts
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