Rheumatology

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The development of inflammatory arthritis and other rheumatic diseases following stem cell transplantation
Seminars in Arthritis and Rheumatism, 04/16/09

Barnabe CCM et al. – The incidence of rheumatic disease development after stem cell transplantation (SCT) is unknown, and reported cases may simply reflect those patients who were predisposed to disease development in the first place. Clinical vigilance in the recognition of phenotypic changes and clinical events occurring after SCT which may represent new autoimmune phenomena is required.

• Literature review to determine the association between SCT and the de novo development of rheumatic conditions
• Use of PubMed and manual searches of references from pertinent articles

• Case reports detailing the onset of the following were identified:
  • RA, HLA-B27-related spondyloarthropathy
  • psoriatic arthritis, systemic lupus erythematosus, vasculitis
  • eosinophilic fasciitis, antiphospholipid antibody syndrome
  • polyarthritis related to intercedent viral infection
• Failure of transmission of autoimmune disease from donor to recipient in 2 case reports is also summarized

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