Rheumatology Medical News about JIA;TNF;inflammatroy activity

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Tumor necrosis factor-α -308 genotypes influence inflammatory activity and TNF-α serum concentrations in children with juvenile idiopathic arthritis
Journal of Rheumatology, 04/09/09

Mourao AF et al. – Study reports that TNF-α -308 GA/AA genotypes were related to higher inflammatory activity and worse measures of disease activity in Portuguese patients with juvenile idiopathic arthritis (JIA); were not associated with susceptibility to JIA.

Methods

Aim was to investigate if clinical measures of JIA activity and TNF-α serum concns were associated with TNF-α -308 genotypes
Portuguese pts with JIA, along with a control group of healthy subjects
Demographic and clinical data and blood samples were collected from each patient
DNA was extracted for analysis of TNF-α gene promoter polymorphisms at position -308 by restriction fragment-length polymorphism

Results

114 pts and 117 controls evaluated:
- 57% of pts presented the oligoarticular subtype
- 25% the polyarticular subtype
- 8% the systemic subtype
- 9% had enthesitis-related arthritis
- and 5% psoriatic arthritis
24% pts presented the -308 GA/AA genotypes, and 76% the -308 GG genotype, similar to findings in controls
Pts with the -308 GA/AA genotype had higher:
- degree of functional impairment
- erythrocyte sedimentation rate
- 100-mm VAS score for disease activity
- and TNF-α levels vs -308 GG genotype