Rheumatology

Your Article Summary

See Latest Articles

Acute septic arthritis revisited: A prospective study in 93 patients correlating C-reactive protein levels with duration of intravenous antibiotic therapy, clinical and radiological outcomes
European Journal of Orthopaedic Surgery & Traumatology, 04/03/09

Jain S et al. – Study reports that C-reactive protein (CRP) levels decrease consistently during the antibiotic therapy and patients in whom CRP values return to normal earlier have good clinical and radiological outcomes. Intravenous antibiotics should be stopped and switched over to oral therapy once CRP levels return to normal.

• Aim was to find the optimal duration of iv antibiotic therapy for acute septic arthritis after surgical drainage
• A prospective study in 93 pts; age <5 yrs, who presented with acute septic arthritis
• These pts were treated with arthrotomy and sequential antibiotic therapy based on determination of serial quantitative CRP levels correlating radiological and clinical outcome

• 84% of pts had CRP values ≥96 mg/dl at the time of presentation
• More than half of the subjects had CRP values reverted to normal by the seventh day of treatment
• By the 21st day of treatment, all the subjects had CRP values at baseline levels
• The clinical and radiological outcome was excellent in 85% of the cases where the CRP normalized by 7 days vs 25% where the CRP had not normalized

Related Articles

See all related articles

Optimizing Antimicrobial Therapy in Sepsis and Septic Shock
Critical Care Clinics, 11/06/09    Relevance Score: 69%

Inadequate Antibiotic Therapy in Solid Organ Transplant Recipients is Associated with a Higher Mortality Rate
Surgical Infections, 10/01/09    Relevance Score: 69%

Role of antibiotic lock therapy for the treatment of catheter-related bloodstream infections
The International Journal of Artificial Organs, 11/18/09    Relevance Score: 68%

Pros and cons of antibiotic therapy for pouchitis
Expert Review of Gastroenterology & Hepatology, 10/13/09    Relevance Score: 68%

Therapy of community-acquired acute bacterial meningitis: the clock is running
Expert Opinion in Pharmacotherapy, 10/20/09    Relevance Score: 67%

Today in Infectious Arthritis...keeping you current

Receive free subspecialty "5-minute updates" via email

Treatment approaches to prosthetic joint infections: results of an Emerging Infections Network survey
Diagnostic Microbiology and Infectious Disease, 12/11/09

Detection of Chlamydia trachomatis- DNA in synovial fluid: evaluation of the sensitivity of different DNA extraction methods and amplification systems
Arthritis Research & Therapy, 11/25/09

CD23 mediates anti-mycobacterial activity of human macrophages
Infection and Immunity, 10/20/09

 See all of Infectious Arthritis