Rheumatology Medical News about systemic sclerosis;hypoxia-inducible factor 1A gene polymorphisms

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Association of hypoxia-inducible factor 1A ( HIF1A ) gene polymorphisms with systemic sclerosis in a French European Caucasian population
Scandinavian Journal of Rheumatology , 03/26/09

Wipff J et al. – Study reports an association between the hypoxia-inducible factor 1A (HIF1A) gene and Systemic sclerosis (SSc) in a European Caucasian population, supporting its role in the pathophysiology of SSc.

Methods

Study to determine whether polymorphisms of the HIF1A gene affects susceptibility to SSc in a large French European Caucasian population
659 SSc pts and 511 healthy matched controls
3 tag SNPs of the HIF1A gene (rs12434438 A/G, rs1957757 C/T, and rs11549465 C/T) were genotyped

Results

Frrequency of of genotypes carrying at least one G allele (A/G and/or GG) of the rs12434438 SNP was higher in SSc pts vs controls
Heterozygous genotype A/G was associated with SSc with the limited cutaneous form of SSc and with positive anti-centromere Abs
No association was detected for the remaining two HIF1A SNPs tested
Haplotype analyses did not detect any association with SSc

<< Previous
Incidence of cancer among patients with systemic sclerosis in...

Next >>
Association between the interleukin 23 receptor and ankylosing...