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Doppler myocardial imaging compared to standard two-dimensional and doppler echocardiography for assessment of diastolic function in patients with systemic amyloidosis
Journal of the American Society of Echocardiography, 03/24/09

Al-Zahrani GB et al. - Study reports that standard pulsed wave tissue Doppler imaging (PW-TDI) of the mitral annulus was the most accurate diastolic measure to detect early left ventricular dysfunction in patients with AL amyloidosis. However, no diastolic measure approached the accuracy of longitudinal systolic cDMI measurements with normal standard 2D and Doppler examinations, compared to controls.

• Study to investigate the role of diastolic color Doppler myocardial imaging (cDMI), to assess distolic dysfunction in pts with cardiac amyloidosis (AL)
• 238 pts, and 39 age and sex-matched controls
• Left ventricular diastolic cDMI measures were compared to test if diastolic dysfunction occurs before longitudinal left ventricular systolic dysfunction

• Standard PW-TDI of the mitral annulus was the most accurate technique to detect early diastolic dysfunction
• However, systolic longitudinal peak cDMI measures outperformed all of the diastolic measures
• No evidence of cardiac involvement on standard 2D and Doppler evaluation, from controls was noted

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