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See Latest ArticlesAchievement of a state of inactive disease at least once in the first 5 years predicts better outcome of patients with polyarticular juvenile idiopathic arthritis
Journal of Rheumatology, 03/24/09
Magnani A et al. - Attainment of the state of inactive disease in children with juvenile idiopathic arthritis (JIA) at least once in the first 5 yrs was found to be associated with less long term joint damage and with a trend toward less functional impairment.
Methods- Study to investigate whether the achievement of inactive disease in the first 5 yrs predicts a more favorable outcome of children with JIA
- Clinical charts of 123 pts who started taking MTX, followed for at least 5 yrs, and received a yearly assessment in the first 5 yrs were reviewed
- At each yearly visit, the presence of inactive disease was assessed
- Pts were divided into 3 groups:
- pts who never reached inactive disease
- pts who reached inactive disease in only 1 visit
- and pts who reached inactive disease in ≥2 visits
- Outcome was evaluated after 6-18 yrs by assessing the following clinical measures:
- restricted joint count
- Childhood Health Assessment Questionnaire (CHAQ)
- Juvenile Arthritis Damage Index (JADI)
- and Poznanski score of radiographic damage
- In the first 5 yrs, 50.4% pts had active disease at their yearly visit
- 32.5% had inactive disease only once
- 17.1% had inactive disease in ≥2 visits
- Pts who achieved inactive disease ≥1 times had lower restricted joint count and JADI-Articular score at last f/u visit than those who never reached such a state
- A similar trend was observed for CHAQ and Poznanski score of radiographic damage
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