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See Latest ArticlesAssociation between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case–control study and meta-analysis of published series
Rheumatology, 03/26/09
Karaderi T et al. – Study concludes that IL-23R polymorphisms are clearly associated with ankylosing spondylitis (AS), but the primary causal association(s) is(are) still not established. These polymorphisms could contribute either increased or decreased susceptibility to AS.
Methods- A meta-analysis with the previously published studies, to refine associations of IL-23R polymorphisms with AS
- In the extended study, the 730 cases were combined with 1088 published cases
- Allelic associations were analysed using contingency tables
- In the meta-analysis, 3482 cases and 3150 controls from 4 different published studies and the new UK cases were combined
- In the UK case–control study with new cases, 4/8 SNPs showed associations
- In the extended UK study, 7/8 IL-23R SNPs showed associations with AS, maximal with rs11209032 when cases with IBD and/or psoriasis were excluded
- Associations with all 8 SNPs
- Strongest associations were again seen not only with rs11209032 but also with rs11209026
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Receive free subspecialty "5-minute updates" via email
Programmed cell death 1 gene polymorphisms is associated with ankylosing spondylitis in Chinese Han population
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