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See Latest ArticlesAutoantibodies in pediatric systemic lupus erythematosus: Ethnic grouping, cluster analysis, and clinical correlations
Journal of Rheumatology, 03/19/09
Jurencak R et al - Ethnic differences in autoantibody profiles were observed in pediatric-onset systemic lupus erythematosus (pSLE). Autoantibodies tended to cluster together and these clusters were associated with different clinical courses.
Methods- Aim was to evaluate the spectrum of serum autoantibodies in pSLE with a focus on ethnic differences
- Pts seen over an 8-yr period; ethnicity, clinical, and serological data collected from 156/169 patients (92%)
- Frequencies of 10 selected autoantibodies among ethnic groups were compared
- There were differences only in the prevalence of anti-U1RNP and anti-Sm Abs, which occurred more frequently in non-Caucasian pts
- Cluster analysis revealed 3 autoantibody clusters
- Cluster 1: anti-dsDNA antibodies
- Cluster 2: anti-dsDNA, antichromatin, antiribosomal P, anti-U1RNP, anti-Sm, anti-Ro and anti-La autoantibody.
- Cluster 3: anti-dsDNA, anti-RNP, and anti-Sm autoantibody
- Highest proportion of Caucasians was in cluster 1, characterized by a mild disease with infrequent major organ involvement vs cluster 2 or cluster 3
- Cluster 2 had the highest frequency of nephritis, renal failure, serositis, and hemolytic anemia
- Cluster 3, which was characterized by frequent neuropsychiatric disease and nephritis
Today in Autoimmune/Heritable...keeping you current
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Clinical and histologic evidence of salivary gland restoration supports the efficacy of rituximab treatment in Sjögrens syndrome
Arthritis & Rheumatism, 11/06/09
Vaccination, atherosclerosis and systemic lupus erythematosus
Lupus, 11/05/09
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Arthritis & Rheumatism, 11/11/09
Today in Pediatric Rheumatology...keeping you current
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Patients perceptions of drug information given by a rheumatology nurse: A phenomenographic study
Musculoskeletal Care, 11/13/09
Monitoring methotrexate toxicity in juvenile idiopathic arthritis
Journal of Rheumatology, 11/18/09
Comparison of clinical versus ultrasound-determined synovitis in juvenile idiopathic arthritis
Arthritis Care and Research , 11/02/09
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