Rheumatology Medical News about fibromyalgia;medically unexplained symptoms

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Fibromyalgia and related medically unexplained symptoms: A lost link between cardiovascular and nociception modulation
Journal of Musculoskeletal Pain , 03/23/09

Fontenele JB et al. – Study proposes two novel hypotheses: Fibromyalgia syndrome (FMS) would be related to a derangement in cardiovascular autonomic control secondary to endothelial function disturbance, and this cardiovascular derangement could correlate with attenuation of supraspinal descending nociceptive inhibition through an integrated central nervous system modulation.

Methods

A review to provide the current evidence about FMS, its relation to cardiovascular alterations, and to propose a new model upon its physiopathogenesis

Results

FMS pts have a greater incidence of orthostatic intolerance, characterized by pre-syncope symptoms, and a relentless activated sympathetic system
Orthostatic intolerance has a causal link to FMS
Alterations in small vessel tone and endothelial function of skeletal muscle or splanchnic vascular beds are crucial to the development of orthostatic intolerance

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Changes in Hippocampal Metabolites After Effective Treatment for Fibromyalgia: A Case Study
The Clinical Journal of Pain, 10/20/09 Relevance Score: 94%

Womens narratives on experiences of work ability and functioning in fibromyalgia
Musculoskeletal Care, 10/23/09 Relevance Score: 93%

General symptom reporting in female fibromyalgia patients and referents: a population-based case-referent study
BMC Public Health, 11/04/09 Relevance Score: 90%

Fibromyalgia: From treatment to rehabilitation
European Journal of Pain, 11/17/09 Relevance Score: 89%

Are chronic fatigue syndrome and fibromyalgia the same? Implications for the provision of appropriate mental health intervention
Journal of Psychiatric and Mental Health Nursing, 11/16/09 Relevance Score: 89%