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Aging and Osteoarthritis: The Role of Chondrocyte Senescence and Aging Changes in the Cartilage Matrix
Osteoarthritis and Cartilage , 03/17/09
Loeser RF et al. - The effects of aging on chondrocytes and their matrix result in a tissue that is less able to maintain homeostasis when stressed, resulting in breakdown and loss of the articular cartilage, a hallmark of osteoarthritis. A better understanding of the basic mechanisms underlying senescence and how the process may be modified could provide novel ways to slow the development of osteoarthritis.
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