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First acute gout attacks commonly precede features of the metabolic syndrome
Journal of Clinical Rheumatology (JCR), 03/10/09

Hernández-Cuevas CB et al. - First attacks of gout may precede the diagnosis of metabolic abnormalities and associated diseases, and provids a unique opportunity to diagnose, prevent, and/or retard long-term complications in these patients.

• Aim was to determine in gout pts, the temporal relationship between the first gout attack and the diagnosis of metabolic syndrome (MS), its components and complications
• Variables: demographic, clinical, and biochemical data, hypertension, hypertriglyceridemia, low HDL, obesity, hyperglycemia or diabetes, MS, ischemic heart disease (IHD), and chronic renal failure (CRF)
• Age and date of the diagnosis of first acute gout attack and associated diseases were obtained

• 7 pts (96% men); mean age at onset, mean age at inclusion, and mean duration of the disease were 39.7 ± 13, 52.5 ± 13, and 13.7 ± 9.9 yrs, respectively
• In 90%, the first attack of gout preceded the diagnosis of features of MS, MS itself or its complications (CRF and IHD)
• 9.8% had previous diagnosis of at least 1 associated disease
• At the time of inclusion, 93% had at least 1 associated disease
• Most pts had no diagnosis of any associated disease previous to first bouts

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