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Development of leprosy in a patient with ankylosing spondylitis during the infliximab treatment: reactivation of a latent infection
Clinical Rheumatology, 03/11/09

Lopes RV et al. - The authors report the case of a 58-year-old man with ankylosing spondylitis, receiving infliximab treatment, who presented with multiple plaques on the face, chest, and extremities, a thickened, tender ulnar nerve, and severe neuritis of the feet. The results of a biopsy of these lesions revealed histopathological features of lepromatous Hansen disease. The use of anti-tumor necrosis factor biologic agent on this patient may have resulted in either a new infection or reactivation of a latent infection of Mycobacterium leprae.

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