Rheumatology Medical News about systemic-onset JIA;heme oxygenase-1

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The role of heme oxygenase-1 in systemic-onset juvenile idiopathic arthritis
Modern Rheumatology, 03/10/09

Takahashi A et al. - Data suggest that the serum level of heme oxygenase-1 (HO-1) may be a useful marker for the differential diagnosis of systemic-onset juvenile idiopathic arthritis (s-JIA). Further study to elucidate the mechanism of HO-1 production and to clarify the role of HO-1 in the disease process is warranted.

Methods

Study to compare serum levels of HO-1 in 56 pts with s-JIA vs healthy controls and pts with other pediatric rheumatic diseases
Serum HO-1 levels were measured by the sandwich ELISA
The serum levels of HO-1, cytokines and cytokine receptors in pts with s-JIA were also assessed at both the active and inactive phases

Results

Mean serum HO-1 level in s-JIA pts during the active phase was 123.6 ± 13.83 ng/ml, higher than that in pts with polyarticular JIA, Kawasaki disease, SLE, or mixed connective tissue disease
The serum HO-1 level in pts with s-JIA in the active phase was greater than in pts with disease in the inactive phase
An assessment of the relationships between serum HO-1 levels and other laboratory parameters or cytokines in pts with s-JIA did not reveal any strong correlations

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