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Interstitial lung disease in polymyositis and dermatomyositis
Clinical Rheumatology, 03/09/09
Chen IJ et al. - Study reports that poor survival in interstitial lung disease (ILD) patients was associated with male gender, a Hamman–Rich-like presentation, and a clinical diagnosis of acute interstitial pneumonia.
Methods- Aim was to estimate the prevalence, characteristics, and prognostic factors of ILD in pts with polymyositis (PM) and dermatomyositis (DM)
- The medical records of 151 PM/DM pts were retrospectively reviewed
- 19.9% PM/DM pts had developed ILD
- Older age at PM/DM onset, anti-Jo-1 Ab, and arthritis/arthralgia were associated with the presence of ILD
- An older age at onset above 45 yrs and arthritis/arthralgia at onset were the 2 independent risk factors for developing ILD
- An older age at onset >45 yrs and anti-Jo-1 positive were associated with ILD
- While arthritis/arthralgia was no longer significant
- Of the 30 ILD pts, 16 (53.3%) died
- The survival time was shorter in ILD pts vs w/o ILD
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