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Disease control and health-related quality of life in juvenile idiopathic arthritis
Arthritis Care and Research , 03/09/09

Seid M et al. - Although disease activity and clinical symptoms in pts with juvenile idiopathic arthritis (JIA) are related to health-related quality of life (HRQOL), considerable unexplained variation in HRQOL exists. HRQOL needs to be assessed independently regardless of clinical status.

Methods

Study to examine variability in HRQOL in children with JIA experiencing no or minimal clinical symptoms, and in a subgroup with polyarticular JIA treated with biologic agents for 12 mo
3 samples were defined using a database of pts ages 2-18 yrs with JIA (n=524), and children (n=31) with polyarticular JIA treated with biologic agents for 12 mo
HRQOL was measured using the Pediatric Quality of Life Inventory (PedsQL) and the percentage of pts with suboptimal HRQOL was determined

Results

Suboptimal HRQOL by self-report occurred in 20.6% PV with at least 1 indicator of minimal symptoms, and in 7.9% PV with all 4 measures indicating minimal symptoms
For children with polyarticular JIA treated for 12 mo with biologic agents, 25.9% pts by self-report and 35.7% pts by parent report were in the suboptimal range of HRQOL

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