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See Latest ArticlesAssociation of the autoimmunity locus 4q27 with juvenile idiopathic arthritis
Arthritis & Rheumatism, 03/05/09
Albers HM et al. - Findings suggest that the 4q27 locus, previously reported to be associated with rheumatoid arthritis (RA), type 1 diabetes mellitus, celiac disease, and psoriatic arthritis, is also associated with susceptibility to juvenile idiopathic arthritis (JIA).
Methods- Study to investigate the possible role of the 4q27 locus in JIA
- The rs6822844 marker in the 4q27 locus was genotyped in 655 Caucasian JIA pts, and 791 healthy controls divided into two sets
- A 5% decrease in T allele frequency was observed in pts in the first set
- In the second set, a 3% decrease was observed
- The combined data set generated an OR of 0.76
- When the different JIA subtypes were analyzed individually, significant decreases were seen in the subtypes with a polyarticular course of disease and rheumatoid factor-negative polyarthritis
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