Rheumatology Medical News about JIA;anti-rheumatic drugs

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Recent developments in anti-rheumatic drugs in pediatrics: Treatment of juvenile idiopathic arthritis
Arthritis Research & Therapy, 02/26/09

Hayward K et al. – Article summarizes recent developments in the medical treatment of children with juvenile idiopathic arthritis (JIA) and offer insights into emerging therapies. Advances in the understanding of the immune system have shed light on pathways involved in inflammation and self tolerance that provide new targets for treatment of rheumatologic conditions. Biologic agents have been designed to target key cytokines implicated in JIA, including TNF-α, IL-1, IL-6 as well as signaling molecules involved in the regulation of B-cell and T-cell lymphocyte responses. Although promising results have been demonstrated with these medications, the blockade of such important biologic pathways necessitates careful safety monitoring for infection risks, responses to vaccinations, possible neurologic side effects and long-term effects on immune surveillance and possible risks of malignancy.

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Monitoring methotrexate toxicity in juvenile idiopathic arthritis
Journal of Rheumatology, 11/19/09 Relevance Score: 90%

B lymphocyte stimulator expression in pediatric systemic lupus erythematosus and juvenile idiopathic arthritis patients
Arthritis & Rheumatism, 11/04/09 Relevance Score: 89%

Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis
Arthritis Research & Therapy, 10/06/09 Relevance Score: 89%

Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis
Arthritis & Rheumatism, 11/09/09 Relevance Score: 87%

Systemic JIA: new developments in the understanding of the pathophysiology and therapy
Best Practice & Research: Clinical Rheumatology, 10/28/09 Relevance Score: 85%