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See Latest ArticlesMyocardial performance and aortic elasticity are impaired in patients with ankylosing spondylitis
Scandinavian Journal of Rheumatology , 02/24/09
Moyssakis I et al. – Patients with ankylosing spondylitis (AS) and no clinical evidence of cardiac disease have increased stiffness of the aorta and decreased global myocardial performance and both of these abnormal measurements correlate with disease activity. The abnormal Tei index may reflect an early manifestation of cardiac dysfunction in these pts.
Methods- Aim was to measure aortic stiffness and global left ventricular (LV) function in pts with AS and no clinical evidence of heart disease
- 47 pts (54 males, 3 females, mean age 41.78 yrs) w/o clinical evidence of cardiac involvement and 78 healthy subjects underwent complete echocardiographic study
- Aortic stiffness was determined non-invasively by aortic distensibility (AoD)
- Global LV function was evaluated by the myocardial performance index (the Tei index)
- AoD in pts was decreased vs controls, confirming that aortic stiffness is increased in AS
- The LV Tei index was increased in the pt group vs control
- Ejection fraction (EF) did not differ between the two groups
- AoD was associated with BASDAI and LV isovolumic relaxation time (IVRT)
- LV Tei index was associated with BASDAI and the LV mass index
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