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Crystal ball gazing: New therapeutic targets for hyperuricaemia and gout
Rheumatology, 02/20/09
Dalbeth N et al. – Article summarizes the recent advances in understanding of the basic biology of hyperuricaemia and gout, with important implications for future treatment. These findings include:
- Genetic variation within SLC2A9 as a key regulator of urate homeostasis
- Identification of urate—anion exchanger urate transporter 1 (URAT1) and other renal uric acid transporters
- Recognition of urate as an endogenous danger signal and activator of the adaptive immune response
- These observations suggests an important role for urate crystals in non-microbial immune surveillance
- Possible new therapeutic targets: NALP3 inflammasome, and IL-1β
- Disordered osteoclastogenesis in pts with chronic gout highlights potential therapies for prevention of joint damage
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Common Polymorphisms Influencing Serum Uric Acid Levels Contribute to Susceptibility to Gout, but Not to Coronary Artery Disease
PLoS ONE - Cardiovascular Disorders, 11/10/09
The modern management of gout
Rheumatology, 10/08/09
Hyperuricemia Is a Mediator of Endothelial Dysfunction and Inflammation in Renal Allograft Recipients
Transplantation Proceedings, 11/02/09
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