Rheumatology Medical News about systemic sclerosis;anti-CENP-B;Anti-Sc170 antibody

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Clinical associations of anti-CENP-B and anti-Scl70 antibody levels measured by multiplexed fluorescent microsphere immunoassay in systemic sclerosis
Rheumatology International, 02/11/09

Volpe A et al. – The findings support the association of high levels of anti-Scl70 antibodies with a worse cutaneous involvement, while high levels of anti-CENP-B antibodies seem to have a protective effect on skin manifestations in systemic sclerosis (SSc).

Methods

Study to assess the association between anti-CENP-B and anti-Scl70 Ab levels, and the clinical features in pts affected by SSc
Clinical evaluation of 80 scleroderma pts performed to evaluate disease activity and organ involvement
Scleroderma-specific autoantibodies were detected using multiplexed fluorescent microsphere immunoassay

Results

11 pts were positive for both anti-Scl70 and anti-CENP-B antibodies; 6 cases showed a weak positivity for 1 of the two autoantibodies and a stronger positivity for the other one
5 cases showed an intense positivity for both autoantibodies
This latter subgroup was excluded from the analysis of the associations between autoantibody levels and the clinical features
In the anti-CENP-B positive pts higher Ab levels were associated with a less extensive vs more extensive skin involvement
In the anti-Scl70 positive pts autoantibody levels were directly correlated with skin involvement; higher levels in pts with a more extensive vs less extensive skin involvement

<< Previous
Clinical and serological correlates of anti-Sm autoantibodies in...

Next >>
Comparison of the effectiveness and tolerability of lidocaine...