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A role of IgM antibodies in monosodium urate crystal formation and associated adjuvanticity
Journal of Immunology, 02/12/09

Kanevets U et al. – Study reports that mouse serum contains IgM Abs that bind to monosodium urate (MSU) crystals via their F(ab')₂ fragment. They also facilitate their precipitation, explaining the mechanism of accelerated uric acid precipitation in vivo, and may provide a testable hypothesis for the pathogenesis of gout.

Methods

Aim was to investigate as to why uric acid precipitates rapidly in vivo, in sharp contrast to the minimal crystallization in vitro

Results

A group of IgM Abs could bind to uric acid crystals
B cell-deficient mice did not sense the proinflammatory adjuvant effect of uric acid
The titers of these Abs increased upon immunization with uric acid crystals
The purified IgM Abs could facilitate uric acid precipitation to form the inflammatory crystals in vitro
Infusion of these Abs into B cell-deficient mice increased the basal level of inflammation and restored the host’s ability to sense uric acid’s adjuvanticity
This factor could function as an endogenous adjuvant, suggesting a new mechanism of the pathogenesis of gouty arthritis and uric acid-induced immune activation

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