Rheumatology Medical News about diffuse cutaneous systemic sclerosis; myeloid cell adhesion;adhesion molecule-A

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Junctional adhesion molecule-A is abnormally expressed in diffuse cutaneous systemic sclerosis skin and mediates myeloid cell adhesion
Annals of Rheumatic Diseases, 02/16/09

Hou Y et al. – Junctional adhesion molecule A (JAM-A) expression is dysregulated in systemic sclerosis (SSc) skin. Its decreased expression on endothelial cells may result in a reduced response to proangiogenic bFGF, while increased expression on fibroblasts may serve to retain myeloid cells, which in turn secrete angiogenic factors.

Methods

Study to investigate the role of JAM-A in pathogenesis of SSc
Biopsies obtained from proximal and distal arm skin; serum obtained from pts and normal (NL) volunteers
Cell surface ELISAs and immunohistology were performed
An ELISA was designed to determine the amount of soluble JAM-A (sJAM-A) in serum
Myeloid U937 cell-SSc dermal fibroblast and skin adhesion assays were performed to determine the role of JAM-A in myeloid cell adhesion

Results

Stratum granulosum and dermal endothelial cells (ECs) from distal arm SSc skin exhibited decreased expression of JAM-A vs NL
sJAM-A was elevated in the serum of pts with SSc
Conversely, JAM-A was increased on the surface of SSc vs NL dermal fibroblasts
JAM-A accounted for a significant portion of U937 binding to SSc dermal fibroblasts
In addition, JAM-A contributed to U937 adhesion to both distal and proximal SSc skin

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