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Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration
Arthritis Research & Therapy, 02/04/09
Andreas K et al. - Findings indicate that rheumatoid arthritis-relevant stimuli result in the molecular activation of catabolic and inflammatory processes in human chondrocytes that are reverted by antirheumatic treatment. Candidate genes that evolved in this study for new therapeutic approaches include suppression of specific immune responses (COX-2, IL23A, IL6) and activation of cartilage regeneration (CTGF, CYR61).
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