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Pregnancy in patients with ankylosing spondylitis: Do regulatory T cells play a role?
Arthritis Care and Research , 02/03/09

Förger F et al. - Study documents that pregnancy influenced the expansion and cytokine secretion of regulatory T (Treg) cells in both patients with ankylosing spondylitis (AS) and control subjects. However, the Treg cells of pregnant pts with AS failed to support an antiinflammatory cytokine milieu, thereby possibly contributing to the persistent disease activity during pregnancy.

• Aim was to investigate the numerical and functional changes of CD4+CD25^high Treg cells during pregnancy and postpartum in pts with AS
• Frequency was determined by flow cytometry in 10 pregnant and 5 nonpregnant pts and 14 pregnant and 4 nonpregnant healthy controls
• Pregnant individuals were investigated at third trimester and 8 wks postpartum
• Treg cells and CD4+CD25- effector T (Teff) cells were investigated for proliferation and cytokine secretion after stimulation with anti-CD3 and anti-CD28 monoclonal Abs

• Frequency of CD4+CD25^high Treg cells was higher during pregnancy than postpartum in both healthy control and pts
• Treg cells in pregnant women with AS secreted only small amounts of IL-10 and showed lower suppression of TNF-α and interferon-γ secretion by CD4+CD25- Teff cells
• At postpartum time point, proinflammatory cytokine levels in the Treg/Teff cell cocultures and Teff cell monocultures were higher in pts

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