Rheumatology Medical News about serum uric acid level; all cause mortality

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Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: A Chinese cohort study
Arthritis Care and Research , 02/03/09

Chen JH et al. – Study shows that hyperuricemia was an independent risk factor of mortality from all causes, total cardiovascular disease (CVD), and ischemic stroke in the Taiwanese general population, in high-risk groups, and potentially in low-risk groups.

Methods

Aim was to assess the temporal association between serum uric acid level, hyperuricemia, and cardiovascular mortality
41,879 men, 48,514 women, ages ≥35 yrs
Data collected for total CVD, ischemic stroke, congestive heart failure, hypertensive disease, and coronary heart disease were compared according to increasing serum uric acid levels

Results

21.2% events of 5,427 total deaths were ascribed to CVD
In all pts, HRs were 1.16 for all-cause mortality, 1.39 for total CVD, and 1.35 for ischemic stroke
In subgroup analysis, the HRs for CV risk remained significant in pts with hypertension and in pts with diabetes
In addition, in a low metabolic risk subgroup, the HRs for all-cause mortality and total CV morbidity were 1.24, and 1.48, respectively

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