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See Latest ArticlesMolecular framework for response to imatinib mesylate in systemic sclerosis
Arthritis & Rheumatism, 02/02/09
Chung L et al. – Findings suggest that PDGFRβ and Abl play critical, synergistic roles in the pathogenesis of systemic sclerosis (SSc), and that imatinib targets a gene expression program that is frequently dysregulated in this disease.
Methods- Case study of 2 pts with early diffuse cutaneous SSc (dcSSc), treated with tyrosine kinase inhibitor imatinib mesylate
- Pts showed reductions in cutaneous sclerosis in response to therapy
- IHC analyses of skin biopsy specimens demonstrated reductions of phosphorylated PDGFRβ and Abl with imatinib therapy
- By gene expression profiling, an imatinib-responsive signature specific to dcSSc was identified
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Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis
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Today in Connective Tissue Dz...keeping you current
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Long-term outcome of systemic sclerosis-associated pulmonary arterial hypertension treated with bosentan as first-line monotherapy followed or not by the addition of prostanoids or sildenafil
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