Rheumatology Medical News about children with Henoch-Schoenlein Nephritis

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Correlation of IgA accumulation with clinical findings in children with Henoch-Schoenlein nephritis
Rheumatism, 01/27/09

Kasap B et al. - Findings suggest that renal IgA deposition is not associated with clinical or histological findings in children with Henoch-Schoenlein purpura (HSN). These results need to be confirmed in larger samples.

Methods

Aim was to investigate the influence of renal IgA accumulation on clinical and histopathological findings in children with HSN
17 pts; clinical assessment at baseline and last visit
Renal histopathological changes were graded according to the classification of International Study of Kidney Disease in Childhood
IgA accumulation was quantified as +1 to +4
Based on this, pts were divided into group 1 (+1 or +2 accumulation) and group 2 (+3 or +4 accumulation)
All parameters were compared between the groups

Results

No significant difference between the groups with respect to clinical findings and histopathological changes
Amount of IgA accumulation was not correlated with clinical or histopathological status

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