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Prepubertal Girls with Premature Adrenarche Have Greater Bone Mineral Content and Density Than Controls
Journal of Clinical Endocrinology and Metabolism, 11/12/01
Print     Email This Article     Save in My Library   Free Abstract
These data suggest a specific effect of PA on bone mineral, but not on other lean body components. The absence of a correlation between bone age and bone mineral in this small group leads us to propose there are separate promoters of bone age advancement and bone mineral accrual. Candidate hormones for these processes include adrenal androgens, E, and IGF-I. The findings of this study suggest that hormonal alterations associated with PA affect bone mineral accrual and may elucidate the mechanisms involved in this process
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