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See Latest ArticlesResident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout
Arthritis & Rheumatism, 01/05/09
Martin WJ et al. – These data indicate that resident macrophages, rather than infiltrating monocytes or neutrophils, are important for initiating and driving the early proinflammatory phase of acute gout.
Methods- Aim was to determine whether infiltrating monocytes, neutrophils, or resident macrophages contribute to the early inflammatory response to monosodium urate monohydrate (MSU) crystals in vivo
- A peritoneal model of acute gout was used
- Production of proinflammatory cytokines (IL-1β TNF-α, IL-6) by resident macrophages, infiltrating monocytes, and neutrophils determined by flow cytometry
- Infiltrating and resident peritoneal cells were cultured with MSU crystals ex vivo; proinflammatory cytokine production determined by multiplex cytokine array
- Activated macrophages on the visceral epithelial lining of the peritoneum were identified by immunofluorescence histochemistry
- Production of cytokines in vivo preceded the influx of Gr-1intermediate 7/4+ monocytes
- Monocytes and neutrophils recruited failed to produce proinflammatory cytokines either in vivo, or ex vivo following restimulation with MSU crystals
- Stimulation of the naive peritoneal resident cell population resulted in positive staining of resident macrophages for the proinflammatory cytokines IL-1β, TNF-α, and IL-6
- Depletion of the resident macrophage population resulted in decrease in both MSU crystal-induced neutrophil infiltration and proinflammatory cytokine production in vivo despite the presence of infiltrating monocytes
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