Rheumatology Medical News about JIA;IL2RA/CD25

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Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis
Arthritis & Rheumatism, 01/09/09

Hinks A et al. – Data provides evidence that the interleukin-2 receptor α(IL2RA/CD25) gene represents a juvenile idiopathic arthritis (JIA) susceptibility locus; further investigation required.

Methods

Study to determine whether SNPs within the IL2RA/CD25 gene are associated with JIA
3 SNPs within the IL2RA/CD25 gene were selected for genotyping in UK JIA cases (n=654) and controls (n=3,849)
Data for 1 SNP (rs2104286) from North American JIA cases (n=747) and controls (n=1,161)

Results

SNP rs2104286 within the IL2RA/CD25 gene was associated with UK JIA cases
A second SNP (rs41295061) also showed modest evidence for association with JIA
Association with rs2104286 was convincingly replicated in the North American JIA cohort
Meta-analysis of the 2 cohorts yielded highly significant evidence of association with JIA

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