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See Latest ArticlesElevated synovial expression of triggering receptor expressed on myeloid cells-1 (TREM-1) in patients with septic arthritis or rheumatoid arthritis
Annals of Rheumatic Diseases, 12/09/08
Collins CE et al. – Synovial TREM-1 expression is elevated in septic arthritis and rheumatoid arthritis (RA); targeting TREM-1 may have therapeutic benefits by reducing local proinflammatory cytokine and chemokine release.
Methods- Aim was to determine whether synovial expression of TREM-1 is up-regulated in pts with distinct types of inflammatory or non-inflammatory arthritis
- Synovial fluid (SF) analyzed for soluble TREM-1 (sTREM-1), TNFα and leukocyte TREM 1 mRNA
- Synovial tissue from 4 RA pts, 2 pts with Crohn’s associated arthritis, 1 with AS, and 1 with OA examined for TREM-1 expression by IHC
- 3 of the RA samples also analyzed by WB
- SF sTREM-1 levels in septic arthritis and RA were similar to each other; greater than gouty arthritis, non-septic/non-RA inflammatory arthritis, and non-inflammatory arthritis
- SF TNFα and sTREM-1 levels correlated with each other
- sTREM-1 and leukocyte TREM-1 mRNA levels each correlated with SF leukocyte counts
- TREM-1 in RA was expressed in situ in synovial tissue by cells of myelomonocytic lineage; not detectable in control
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Today in Infectious Arthritis...keeping you current
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Correlation between Vancomycin MIC Values and Those of Other Agents against Gram-Positive Bacteria among Patients with Bloodstream Infections Caused by Methicillin-Resistant Staphylococcus aureus
Antimicrobial Agents and Chemotherapy, 12/03/09
Detection of Chlamydia trachomatis- DNA in synovial fluid: evaluation of the sensitivity of different DNA extraction methods and amplification systems
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CD23 mediates anti-mycobacterial activity of human macrophages
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Today in Rheumatoid Arthritis...keeping you current
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CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production
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No evidence for association of the KLF12 gene with RA in a large UK cohort of >7,000 samples.
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New classification of the shared epitope in rheumatoid arthritis: Impact on the production of various anti-citrullinated protein antibodies
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