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Are glucocorticoids equivalent to NSAIDs for the treatment of gout flares?
Nature Reviews Rheumatology , 12/05/08

Gaffo AL et al. - A short course of moderately high-dose oral glucocorticoids can be considered an effective and safe alternative to NSAIDs for the management of acute gout flares in patients without a history of gastrointestinal, cardiovascular or serious renal disease.

Methods

A trial to determine whether the glucocorticoid prednisolone can be used as an alternative to NSAIDs
Pts (n=120) with monosodium urate crystal-proven acute gout flares
Treatment: oral prednisolone 35 mgx1/d or oral naproxen 500 mgx2 for 5 days

Results

A nonsignificant difference between the 2 groups
Equivalence between the 2 agents both in the primary and secondary outcome measures
Oral glucocorticoids were as effective and safe alternatives in the management of acute gout flares

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