Rheumatology Medical News about gout and hyperuricemia;febuxostat vs allopurinol

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Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: A 28-week, phase III, randomized, double-blind, parallel-group trial
Arthritis Care and Research , 11/05/08

Schumacher HR et al. - At all doses studied, febuxostat more effectively lowered and maintained serum urate levels <6.0 mg/dl than did allopurinol (300 or 100 mg) or placebo in subjects with hyperuricemia and gout, including those with mild to moderately impaired renal function.

Methods

Study to compare the urate-lowering efficacy and safety of febuxostat, and allopurinol in hyperuricemia and gout pts with impaired renal function
Pts (n=1,072) were randomized to receive febuxostat x1/d (80 mg, 120 mg, or 240 mg), allopurinol (300 or 100 mg, based on renal function), or placebo for 28 wks

Results

More subjects treated with febuxostat attained the primary end point of last 3 monthly serum urate levels <6.0 mg/dl vs allopurinol and placebo
A higher % of subjects with impaired renal function treated with febuxostat achieved the primary end point
AEs or serious AEs were similar across groups; diarrhea and dizziness more frequent in febuxostat 240 mg group
Primary reasons for withdrawal were similar across groups
Withdrawl because of gout flares was more frequent with febuxostat vs allopurinol

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