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See Latest ArticlesAssociation of three genetic loci with uric acid concentration and risk of gout: A genome-wide association study
The Lancet, 10/17/08
Dehghan A et al. –Three genetic loci associated with uric acid concentration and gout were identified. A score based on genes with a putative role in renal urate handling showed a substantial risk for gout.
Methods- Study to identify novel genes associated with serum uric acid concn and gout
- Genome-wide association studies in two chorts of 7699 and 4148 pts
- SNPs that reached genome-wide association with uric acid in either cohorts were evaluated with gout
- 3 loci in both cohorts showed genome-wide association with uric acid
- Top SNPs in each locus were: missense rs16890979 in SLC2A9, missense rs2231142 in ABCG2, and rs1165205 in SLC17A3
- All SNPs were direction-consistent with gout in white participants
- In black participants rs2231142 was direction-consistent with gout
- An additive genetic risk score of high-risk alleles at the 3 loci showed graded associations with uric acid and gout
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