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Testing the druggable EDG2 knee OA genetic factor for replication in a wide range of sample collections
Annals of Rheumatic Diseases, 09/30/08
Dieguez-Gonzalez R et al. - The original report of a promising genetic association between a druggable G-protein coupled receptor, EDG2, and knee OA has not been replicated. This lack of replication could be due to a modest effect of the promoter polymorphism that will require even larger studies (the winners curse) although a more pronounced effect in the Asian population versus Europeans cannot be excluded.
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