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See Latest ArticlesAlcohol consumption is associated with decreased risk of rheumatoid arthritis; results from two Scandinavian case-control studies
Annals of Rheumatic Diseases, 10/02/08
Källberg H et al. – Recent demonstration of a preventive effect of alcohol in experimental arthritis, indicates that alcohol may protect against rheumatoid arthritis (RA). This highlights the potential role of life-style, and emphasises the advice to stop smoking, but not necessarily to abstain from alcohol in order to diminish risk of RA.
Methods- Study to determine the association between risk of RA and alcohol consumption in combination with smoking and HLA-DRB1 shared epitope (SE)
- Data from two independent case-control studies of RA, the Swedish EIRA and the Danish CACORA
- Alcohol consumption was, more common in controls and dose-dependently associated with reduced risk of RA in both studies
- Among alcohol consumers, the quarter with highest consumption had a decreased risk of RA vs the half with the lowest consumption
- For the subset of RA seropositive for abs to citrullinated peptide antigens, alcohol consumption reduced the risk the most in smokers carrying HLA-DRB1 SE alleles
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