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Lysophospholipids induce the nucleation and extension of beta 2-microglobulin-related amyloid fibrils at a neutral pH
Nephrology Dialysis Transplantation, 09/26/08
Ookoshi T et al. - Haemodialysis patients had significantly higher plasma concentrations of LPA than healthy subjects. Furthermore, uraemic plasmas with the highest ranking LPA concentrations stabilized A beta2M amyloid fibrils significantly more potently than normal plasmas. On the other hand, simple addition of LPA to normal plasma did not enhance the fibril stabilizing activity.
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